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Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances复制

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C Xue, Q Chu, Q Shi, Y Zeng, J Lu, L Li
Signal Transduction and …, 2025
nature.com
The Wnt signaling pathway is critically involved in orchestrating cellular functions such as proliferation, migration, survival, and cell fate determination during development. Given its pivotal role in cellular communication, aberrant Wnt signaling has been extensively linked to the pathogenesis of various diseases. This review offers an in-depth analysis of the Wnt pathway, detailing its signal transduction mechanisms and principal components. Furthermore, the complex network of interactions between Wnt cascades and other key …

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