Adverse effects of antipsychotic medications
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J Muench, AM Hamer
American family physician, 2010
aafp.org
… The first-generation antipsychotics (FGAs) work through dopamine D 2 neuroreceptor blockade, and a subsequent series of new antipsychotics were developed with stronger dopamine blockade. To discuss differences in the adverse effect profiles of FGAs, we use the terms “low-potency” and “high-potency,” not to indicate their clinical effectiveness, but rather to indicate their potency in binding to this dopamine D 2 neuroreceptor. Table 1 outlines selected FGAs, the usual maintenance dosage, and relative potency of dopamine …
