Zuranolone in major depressive disorder: results from MOUNTAIN-a Phase 3, multicenter, double-blind, randomized, placebo-controlled trial.
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AH Clayton, R Lasser, I Nandy, AJ Sankoh…
The Journal of …, 2023
europepmc.org
Objective: To evaluate the efficacy and safety of zuranolone, an investigational neuroactive steroid and GABA A receptor positive allosteric modulator, in major depressive disorder (MDD). Methods: The phase 3, double-blind, randomized, placebo-controlled MOUNTAIN study enrolled adult outpatients with DSM-5-diagnosed MDD, 17-item Hamilton Depression Rating Scale total score (HDRS-17)≥ 22, and Montgomery-Asberg Depression Rating Scale total score≥ 32. Patients were randomized to treatment with zuranolone 20 mg …
