Roles of salt-inducible kinases in cancer
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H Shi, S Chen, B Wang
International Journal of Oncology, 2023
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Salt inducible kinases (SIKs) with three subtypes SIK1, SIK2 and SIK3, belong to the AMP-activated protein kinase family. They are expressed ubiquitously in humans. Under normal circumstances, SIK1 regulates adrenocortical function in response to high salt or adrenocorticotropic hormone stimulation, SIK2 is involved in cell metabolism, controlling insulin signaling and gluconeogenesis and SIK3 coordinates with the mTOR complex, promoting cancer. The dysregulation of SIKs has been widely detected in various types of …
