Physiologically based pharmacokinetics of cyclosporine A: extension to tissue distribution kinetics in rats and scale-up to human
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/9808668
其他信息:
PMID: 9808668
作者: R Kawai; D Mathew; C Tanaka; M Rowland; R Kawai; ...
摘要: The tissue distribution kinetics of i.v. Cyclosporine A (CyA) was investigated extensively in rats. The concentration-to-time data of 11 organs were analyzed separately using local physiologically based pharmacokinetic models, involving nonlinear plasma-to-blood cell distribution, membrane-permeability-limited plasma-to-tissue distribution and either linear or nonlinear tissue binding. Two global physiologically based pharmacokinetic models were then evaluated, each comprising arterial and venou...
