Safety and efficacy of subcutaneous injection with HMI-115 versus placebo in endometriosis-associated pain in premenopausal women: a multicentre, double-blind, randomised, proof-of-concept phase 2 trial
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DOI:
文献链接: https://www.sciencedirect.com/science/article/abs/pii/S3050503825000329
其他信息:
L Zhu, ZJ Chen, H Liu, G Wang, K Dynowski…
The Lancet Obstetrics …, 2025
thelancet.com
Background Endometriosis is a chronic disease characterised by dysmenorrhoea and pelvic pain. There is an urgent unmet need for non-hormonal therapies for endometriosis, particularly for women in their reproductive years. Dysregulation of prolactin signalling, including systemic hyperprolactinaemia, augmented endometrial prolactin synthesis, and aberrant prolactin receptor activation, are implicated in the pathogenesis of endometriosis. This proof-of-concept study assessed the safety and efficacy of HMI-115, a human …
