Structures and mechanism of the human mitochondrial pyruvate carrier
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DOI:
文献链接: https://www.nature.com/articles/s41586-025-08873-8
其他信息:
J Liang, J Shi, A Song, M Lu, K Zhang, M Xu, G Huang…
Nature, 2025
nature.com
Mitochondrial pyruvate carrier (MPC) is a mitochondrial inner membrane protein complex essential for uptake of pyruvate into matrix as the primary carbon source for tricarboxylic acid (TCA) cycle 1, 2. Here, we report six cryo-EM structures of human MPC in three different states: three structures obtained at different conditions in intermembrane space (IMS)-open state with highest resolution of 3.2 Å, a structure of pyruvate-treated MPC in occluded state at 3.7 Å, and two structures in matrix-facing state bound with the inhibitor UK5099 or an …
