Primary mediastinal large B-cell Lymphoma: Biological features, clinical characteristics and current treatment strategies
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L Donzelli, A Di Rocco, L Petrucci, M Martelli
Cancer Treatment Reviews, 2025
Elsevier
Primary mediastinal large B-cell lymphoma (PMBCL) is a distinct subtype of B-cell lymphoma, representing a clinical and therapeutic challenge due to its unique presentation, histopathological features, and treatment response. It primarily affects young adults, with a significant female preponderance, and is characterized by a large anterior mediastinal mass that causes compressive symptoms. Despite its aggressive nature, PMBCL patients have a favorable prognosis, with a 5-year survival rate exceeding 80% when early remission is …
