Research progress of direct and indirect KRAS-targeting protein degraders in KRAS-mutant cancers
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L Jiang, Y Chen, J Zhao, L Zhou, Q Zhou, H Jiang…
Bioorganic …, 2025
Elsevier
The RAS gene, being the most frequently activated proto-oncogene, belongs to the GTPase family. Its primary physiological function is to regulate cell proliferation. The main members of the RAS gene are H-RAS, K-RAS, and N-RAS. Approximately 16% of human cancers are related to RAS proteins. KRAS is the most common oncogene. About 17% of solid tumors have KRAS mutations, which account for around 50%, 80%, and 25% of colorectal cancer, pancreatic cancer, and lung adenocarcinoma, respectively. Currently, significant advances …
