PLIN3: a multifaceted regulator of lipid droplet dynamics and disease pathogenesis
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J Ma, Y Feng, Y Dong, D Yue, Y Wang
Medical Oncology, 2026
Springer
Lipids, as core membrane components, energy stores, and signaling molecules, are indispensable for homeostasis; their dysregulation drives obesity, type 2 diabetes, cardiovascular disease, and non-alcoholic fatty liver disease (NAFLD). Lipid droplets (LDs), originating from the endoplasmic reticulum, are phospholipid-monolayer-enclosed organelles that dynamically interact with mitochondria and peroxisomes, buffering lipotoxicity, sequestering bioactive lipids, and facilitating enzymatic reactions—positioning …
