Penetration and permeation into human skin of fusidic acid in different galenical formulation.
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G Stüttgen, E Bauer
Arzneimittel-forschung, 1988
europepmc.org
The penetration into the horny layer and permeation through the skin of fusidic acid, incorporated in different bases, eg, cream, ointment and a gel (Fucidine), was investigated in vitro in a penetration chamber, using human skin. Whereas the horny layer offers a marked barrier to penetration in normal skin, this barrier can be greatly reduced by damaging the horny layer by adhesive tape stripping. Fusidic acid showed penetration into the different layers of skin which was related to the duration of application, including the penetration …
