Hypertriglyceridaemia and elevated cardiovascular risk: will ANGPTL4 inhibition address both?
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JL Katzmann, U Laufs
2025
academic.oup.com
Comment to:'Safety and efficacy of a novel ANGPTL4 inhibitory antibody for lipid lowering: results from phase 1 and phase 1b/2a clinical studies' by Cummings BB et al.(Lancet 2025; 405: 1923–1934) In the last decade, the armamentarium of therapeutic options to modify lipoprotein metabolism has substantially expanded. The discovery of novel targets involved in lipoprotein metabolism such as proprotein convertase subtilisin/kexin type 9 (PCSK9), apolipoprotein CIII (apo CIII), lipoprotein (a), and angiopoietin-like 3 (ANGPTL3) was one …
