Effects of muscarinic cholinergic receptor antagonists on postnatal eye growth of rhesus monkeys
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M Tigges, PM Iuvone, A Fernandes…
Optometry and Vision …, 1999
journals.lww.com
Purpose. To study a potential role for muscarinic receptors in the inhibition of deprivation-induced excessive axial elongation and myopia in a monkey model. Methods. The right eyes of 20 newborn rhesus monkeys were occluded with a black contact lens. In seven monkeys each, either atropine or pirenzepine was topically applied daily to the occluded eyes. The nonoccluded fellow eyes and both the occluded and nonoccluded fellow eyes of another six monkeys were treated with vehicle solution. Results. After 33 to 39 weeks, in 5 monkeys of …
