Pharmacokinetics and bioavailability of Sinemet CR: a summary of human studies.
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KC Yeh, TF August, DF Bush, KC Lasseter, DG Musson…
Neurology, 1989
europepmc.org
The pharmacokinetics of Sinemet CR, a controlled-release formulation containing carbidopa and levodopa, were investigated in healthy young and elderly volunteers and in patients with Parkinson's disease. Sinemet CR produced more sustained plasma levels of levodopa, carbidopa, and 3-O methyldopa than did conventional Sinemet. In elderly subjects, the corresponding steady-state plasma levels fluctuated in narrower ranges with Sinemet CR than those following the administration of Sinemet. Results indicate a levodopa …
