期刊论文Nimodipine: drug metabolism and pharmacokinetic profile复制

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MA Al-Omar
Profiles of Drug Substances, Excipients and Related …, 2005
Elsevier
Publisher Summary Nimodipine is a dihydropyridine calcium channel blocker derivative, which is used in the treatment of cerebrovascular disorders. Nimodipine is rapidly absorbed from the gastrointestinal tract following oral administration, but undergoes extensive first-pass metabolism in the liver. Nimodipine is extensively metabolized in the liver and undergoes extensive first-pass metabolism. More than 18 metabolites have been detected and identified from the biotransformation of nimodipine. The drug undergoes different …