Unravelling the GIPR agonist versus antagonist paradox
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AE Adriaenssens
Nature Metabolism, 2025
nature.com
The debate over whether to agonize or antagonize GIPR signalling has divided the obesity drug design field. Studies from Gutgesell et al. and Liu et al. represent important first steps towards disentangling divergent neural networks that explain the success of both strategies for promoting weight loss.
