Discovery of the P2x3 Antagonist Hw091077 for the Treatment of Chronic Cough
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Y Zang, Q Li, Y Li, X Ding, L Liu, H Sun, L Qu…
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The P2X3 receptor is an ATP-activated ion channel primarily expressed on peripheral sensory neurons. Its activation triggers cough reflex pathways, making it an attractive target for treating chronic cough and the discovery of P2X3 antagonist has been a long-term pursuit by academia and pharmaceutical companies. However, preliminary antagonists have been hampered by taste disturbances or drug-induced liver injury. Our strategy described herein are maintaining a moderate selectivity between P2X3 and P2X2/3 …
