Conformation Study of a Histamine H2-Receptor Antagonist: Crystal Structures of 2-Acetoxy-N-[3-[m-(1-piperidinomethyl)-phenoxy] propyl] acetamide (Roxatidine …
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T ISHIDA, M DOI, M INOUE…
Chemical and …, 1988
jstage.jst.go.jp
As a part of studies aimed at elucidating the Stereostructure—inhibitory activity relationship of histamine Hz-receptor antagonists, the crystal structures of 2-acetoxy-N-[3-[m—(l-piperidinomethyl) phenoxy] propyl] acetamide (roxatidine acetate) and its hydrochloride salt have been analyzed by the X-ray diffraction method. The neutral and cationic molecules both have similar extended conformations, implying that the molecular conformation of roxatidine acetate is little affected by the hydrochloride salt formation. This is an important …
