An AI-Based OCT System to Detect Diabetic Macular Edema: A Prospective Validation and Noninferiority Randomized Clinical Trial
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S Zhang, A Ran, J Zhou, A Ling, K Sham, Y Zhang…
JAMA, 2026
jamanetwork.com
Importance Screening for diabetic retinopathy using fundus photographs is the global standard of care but results in high false-positive referrals to evaluate diabetic macular edema (DME), placing a substantial burden on specialist eye clinics. Integrating an AI-based optical coherence tomography (AI-OCT) system into screening pathways may reduce potentially unnecessary referrals. Objective To evaluate the diagnostic and referral performance of an AI-OCT system for DME detection within a diabetic retinopathy screening …
