Production of influenza virus in serum-free mammalian cell cultures
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/10494957
其他信息:
PMID: 10494957
作者: O W Merten; J C Manuguerra; C Hannoun; S van der Werf; O W Merten; ...
摘要: Human influenza viruses are routinely isolated and grown in a variety of mammalian cell substrates. However, influenza viruses for use as inactivated vaccine are still produced in embryonated eggs. Using a perfusion culture-based bioreactor process using serum-free medium, both human and equine influenza viruses of different types and subtypes could be produced to high titres. Classical DEAE-dextran microcarriers were found to be more suitable than polyester sponge carriers for virus production....
