Development of an RNA Interference Therapeutic Targeting Angiopoietin-Like Protein 3 for Treatment of Hyperlipidemia
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SC Wong, R Zhu, J Hegge, C Schienebeck…
Circulation, 2018
ahajournals.org
… with ANGPTL3’s role in lowering LDL-C independent of LDLr, the LDLr mice showed LDL-C … fed dyslipidemic rhesus monkeys, close to 90% reduction in serum ANGPTL3 was achieved …