Sleep-pain co-regulation by targeting the 5-HT2A receptor subtype: mechanisms, promises and perils
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SM Ahmadi-Soleimani, H Azizi, O Azizi…
Behavioural Brain …, 2026
Elsevier
AbstractSerotonin (5-HT) receptors, classified as 5-HT1-7, are known to mediate a constellation of physiological functions ranging from cognitive performance to regulation of sleep-wake cycle and pain perception. Although these functions have extensively been studied in association with various types of 5-HT receptors (5-HTRs), co-regulation of wakefulness and nociceptive processing by 5-HT2A subtype has remained largely unaddressed. This research gap is further supported by evidence proposing a bidirectional …
