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D-penicillamine-induced autoimmunity in Brown-Norway rats. Similarities with HgCl2-induced autoimmunity复制

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文献链接: https://pubmed.ncbi.nlm.nih.gov/2139074复制

其他信息:

PMID: 2139074
作者: H Tournade; L Pelletier; R Pasquier; M C Vial; C Mandet; ...
摘要: D-penicillamine (DP) has been previously shown to induce an autoimmune disease in Brown-Norway (BN) rats, characterized by a dermatitis, by the production of antinuclear antibodies, by the formation fo circulating immune complexes, and by linear IgG deposits along the glomerular basement membrane. These manifestations are quite similar to those observed in mercuric chloride (HgCl2)-induced autoimmunity. The mechanism of the latter disease has been recently partly elucidated. The aim of this stud...

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