期刊论文The use of surface tension measurements in the design of antibody-based product formulations复制

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HL Levine, TC Ransohoff, RT Kawahata…
PDA Journal of …, 1991
journal.pda.org
Many proteins in aqueous solution are susceptible to interfacial denaturation and precipitation during mechanical agitation. With the large number of protein parenteral products currently in research or clinical testing, it is important not only to understand this denaturation process but also to develop effective methods for stabilizing the products. Surfactants, such as Polysorbate 80 or sodium dodecyl sulfate (SDS), are frequently used to stabilize parenteral products. While it is a commonly accepted technique, little has been …