K2S2O8-Mediated Bromination/Truce–Smiles Rearrangement/Desulfonylation of N-Arylsulfonyl Acrylamides: Access to β-Brominated Amide Derivatives
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Y Tang, J Huang, J Liang, N Long, J Liu…
The Journal of …, 2026
ACS Publications
A K2S2O8-mediated tandem bromination/Truce–Smiles rearrangement/desulfonylation of N-arylsulfonyl acrylamides with sodium bromide has been developed. This reaction exhibits broad functional group compatibility and scalability, delivering structurally diverse β-brominated amides containing a quaternary carbon center in good yields. Mechanistic studies indicated that the formation of bromine radicals represents the crucial step in this radical cascade transformation. This approach provides a complementary and efficient route …
