H-Terminated Catellani Strategy to Aryl β-Ethanol Enables Collective Total Syntheses of Pyranonaphthoquinone Natural Products
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W Song, C Zhang, Z Jin, J Shen, W Xu, Y Zhang
Organic Letters, 2026
ACS Publications
We report an ipso-H-terminated variant using inexpensive formate as the terminating reagent. Coupling with diverse epoxides provides complementary access to valuable aryl β-ethanols with high regioselectivity. Integration with oxa-Pictet–Spengler and Ullmann reactions enables a collective total synthesis of pyranonaphthoquinone natural products. This strategy features significantly reduced synthetic steps, improved overall yields, and robust conditions, establishing a modular platform for structurally diverse aryl ethanol …
