Population pharmacokinetic characteristics of sirolimus in healthy Chinese subjects and renal transplant patients
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M Wang, D Bao-ling, Y Yin-jin, X Su…
… Journal of Clinical …, 2016
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Aim: To identify the factors affecting the pharmacokinetics (PKs) of sirolimus in healthy Chinese subjects and renal transplant patients. Methods: A population PK model of sirolimus was constructed using dense data from 22 healthy volunteers and sparse data from 105 renal transplant patients. Results: The data were well described by a two-compartment model with first-order absorption. The estimates of absorption rate constant (Ka), clearance (CL/F), and central volume of distribution (V2/F) were 0.24 h-1, 8.81 L/h, and …
