CBP-dependent Wnt/β-catenin signaling is crucial in regulation of MDR1 transcription
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Z Xia, M Guo, H Liu, L Jiang, Q Li, J Peng…
Current cancer drug …, 2015
benthamdirect.com
Aberrant expression of the MDR1-encoded P-glycoprotein (P-gp) is often associated with clinical multi-drug resistance (MDR) leading to poor prognosis and failure of chemotherapy. However, the precise and cooperative molecular mechanism responsible for MDR1 transcription and expression in acquired MDR remains elusive. We, herein, demonstrate that Wnt/β-catenin signal pathway is constitutively activated in Doxorubicin-induced MDR cancer cells, in which nuclear β-catenin specifically interacts with the transcriptional coactivator …
