Cell type-specific contribution of low-density lipoprotein receptor to atherosclerosis
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WH Li, YL Zhang, YF Zhang, Z Yu, L Chen…
Science China Life …, 2026
Springer
Elevated blood low-density lipoprotein (LDL) levels are a major risk factor for cardiovascular disease. Increasing LDL receptor (LDLR) expression effectively reduces blood LDL and serves as a key therapeutic strategy for preventing and treating cardiovascular disease. However, it remains unclear how LDLR in different aortic cells contributes to atherosclerosis progression. In this study, we found that hepatocyte-specific deletion of Ldlr in combination with high-fat, high-cholesterol diet feeding induced hypercholesterolemia and …
