Assessing the harmonization of current total vitamin B12 measurement methods: relevance and implications
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BM Cesana, S da Molin, N Jassam…
Clinical Chemistry …, 2025
degruyterbrill.com
Objectives The UK National Institute for Health and Care Excellence has recommended thresholds for total vitamin B12 (B12) assays with interchangeable results for identifying B12 deficiency. We assessed the agreement between B12 methods, to evaluate whether the thresholds may be assumed applicable to all assays. Methods A total of 19 External Quality Assessment (EQA) exercises (1,791 determinations) based on human subjects-pool materials and 97 serum samples were retrieved to characterize the agreement between …
