Relationship of interleukin-1β blockade with incident gout and serum uric acid levels: exploratory analysis of a randomized controlled trial
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DH Solomon, RJ Glynn, JG MacFadyen…
Annals of internal …, 2018
acpjournals.org
Background: Although studies have shown that interleukin-1β (IL-1β) inhibitors can shorten gout attacks, whether they can prevent gout attacks is unclear. Objective: To examine the relationship among canakinumab, a monoclonal antibody targeting IL-1β; serum uric acid levels; and the incidence of gout attacks. Design: Secondary exploratory analysis of a randomized controlled trial.(ClinicalTrials. gov: NCT01327846) Setting: Many clinical sites in 39 countries. Participants: 10 059 patients with a prior myocardial infarction and a high …
