期刊论文Monitoring stability of meningococcal group C conjugate vaccines; correlation of physico-chemical methods and immunogenicity assays复制

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文献链接: https://pubmed.ncbi.nlm.nih.gov/11214232复制

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PMID: 11214232
作者: M M Ho; X Lemercinier; B Bolgiano; M J Corbel; M M Ho; ...
摘要: Two meningococcal C-CRM197 conjugates differing in oligosaccharide chain length, number of conjugation sites, conjugation chemistry and process were monitored for stability at various temperatures or after repeated freeze-thawing by physico-chemical assays. The results were compared with assessment of immunogenicity in mice, previously shown to correlate with performance of the vaccine in clinical trials. The structural stability of the oligosaccharide chains and the protein carrier varied betwe...