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SMARCA4-driven oncogenic enhancer and transcriptional reprogramming in non-small cell lung cancer复制

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HJ Yang, EJ Kim, SH Song, TY Kim
Cancer Research, 2025
aacrjournals.org
SMARCA4, an ATPase subunit of the SWI/SNF complex, is frequently mutated in cancers and plays a crucial role in chromatin remodeling and gene regulation. However, the mechanisms by which SMARCA4 drives oncogenesis in non-small cell lung cancer (NSCLC) remain poorly understood. In this study, we show that SMARCA4 restoration in SMARCA4-deficient NSCLC cells significantly enhances cell proliferation and migration. ATAC-seq and ChIP-seq analyses revealed that SMARCA4 restoration induces extensive …

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