Targeting sodium channels—challenges for acute pain and the leap to chronic pain
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M Alsaloum, D Vasylyev, SG Waxman
Nature Reviews Neurology, 2025
nature.com
Abstract Treatment of pain is a challenge for almost all clinicians, ranging from general practitioners to subspecialists such as pain medicine physicians, surgeons, neurologists and physiatrists. Over the past few years, clinical studies in people with acute postoperative pain have demonstrated that pain in humans can be reduced by inhibiting Nav1. 8, a sodium channel that is essential for repetitive firing of peripheral pain-signalling neurons and has no essential function in the CNS. This discovery is an important step forward, but pain reduction …
