Epigenetics of Solar Lentigines: Molecular Insights into Photoaging and Skin Pigmentation Disorders
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N Mpofana, MU Makgobole, P Pillay
2025
intechopen.com
Chronic exposure to the sun can significantly impact the skin, often resulting in solar lentigines (SL), also known as age spots. These marks are clear signs of photoaging and hyperpigmentation, particularly in those with fair skin. While traditionally linked to extended ultraviolet (UV) exposure and increased melanocyte activity, SLs are now recognized as involving more profound molecular disruptions. Epigenetic processes play a crucial role in this, modifying gene expression without altering the underlying DNA sequence. These …
