Targeted molecular imaging of c-Met in NSCLC using 68Ga-labeled binding peptide
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X Sun, Z Han, J Yan, Y Liu, C Zhao, K Wang
2019
jnm.snmjournals.org
1042 Objectives: c-Met is a receptor tyrosine kinase, implicating cellular processes including proliferation and apoptosis [1]. Abnormal activation of c-Met pathway plays important role in tumorigenesis, progressionin NSCLC andmediates acquired resistance to epidermal growth factor receptor (EGFR) targeted therapy in NSCLC [2]. Nevertheless, lacking accurate in vivo detection methods for c-Metchallenges the understanding of the underlying c-Met related EGFR-TKI resistance mechanismand overall efficacy of c-Met targeted treatment. In this …
