Down-regulation of Fc (ε) RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody
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DW MacGlashan Jr, BS Bochner…
The Journal of …, 1997
academic.oup.com
Abstract Treatment of allergic disease by decreasing circulating IgE with anti-IgE Abs is currently under clinical study. Based on previous unrelated studies, it appeared likely that Fc (ε) RI expression on basophils and mast cells might also be regulated by levels of circulating IgE Ab. Therefore, the expression of IgE and Fc (ε) RI on human basophils was examined in 15 subjects receiving humanized anti-IgE mAb intravenously. Treatment with the anti-IgE mAb decreased free IgE levels to 1% of pretreatment levels and also resulted in a marked …
