Integrating artificial intelligence and physiologically based pharmacokinetic modeling to predict in vitro and in vivo fate of amorphous solid dispersions
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J Zhu, P Xiong, W Wang, T Lu, D Ouyang
Journal of Controlled Release, 2025
Elsevier
Amorphous solid dispersions (ASDs) have emerged as a pivotal strategy in enhancing the dissolution profiles of poorly water-soluble drugs. Although the apparent dissolution rate (both molecular and colloidal drugs) within ASDs has been determined in past experiments, only molecular drugs in the dissolution can be effectively absorbed in vivo. This study aims to develop a prediction model for the in vitro (molecular dissolution) and in vivo (systemic absorption) fate of ASD formulations by integrating artificial intelligence and physiologically …
