期刊论文[The stability of pilocarpine hydrochloride in eyedrops]复制

DOI:复制

文献链接: https://pubmed.ncbi.nlm.nih.gov/3991781复制

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PMID: 3991781
作者: H Porst; L Kny; H Porst; H Porst; L Kny
摘要: This study investigate the kinetics of the degradation of pilocarpine in aqueous solutions within the therapeutically relevant pH-value range from 2.9 to 6.5. A linear system of first order equations for the kinetics of complex pilocarpine degradation can be derived from the concentration course of decomposed products determined by HPLC. The kinetic parameters calculated from the results of isothermic short-term tests permit the prediction of a five-year durability of non-buffered pilocarpine ey...