Language models reveal a complex sequence basis for adaptive convergent evolution of protein functions
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DOI:
文献链接: https://www.ncbi.nlm.nih.gov/pubmed/40986350
其他信息:
Z Cao, H Zhang, Z Zou
Proceedings of the National Academy of …, 2025
pnas.org
Convergent evolution, or convergence, refers to repeated, independent emergences of the same trait in two or more lineages of species during evolution, often indicating functional adaptation to specific environmental factors. Many computational methods have been proposed to investigate the genetic basis for organismal functional convergence, as an important way to decode the complex sequence–function map of proteins. These methods mostly focus on the convergence of amino acid states at the level of individual sites in …
