Estimation of measurement uncertainty for free drug concentrations using ultrafiltration
1. 系统已在2025-12-03 11:19:23对应助文件进行删除
2. 如有需要请重新发布求助信息
注: 所有应助的资源仅供学习交流使用, 不得违反相关法律法规
DOI:
文献链接:
其他信息:
R Rigo-Bonnin, V Mas-Bosch…
Clinical Chemistry and …, 2025
degruyterbrill.com
Measuring free drug concentrations in plasma (or serum) involves separating unbound fractions using methods such as equilibrium dialysis (ED), ultrafiltration (UF), ultracentrifugation, or gel filtration, followed by analysis through measurement procedures like LC-MS/MS, immunoassay, or spectrophotometry. While ED is considered the reference method, UF is becoming increasingly popular in clinical laboratories due to its efficiency, speed, and ability to process multiple samples quickly. Various commercial UF devices are …
