Estimation of measurement uncertainty for free drug concentrations using ultrafiltration
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R Rigo-Bonnin, V Mas-Bosch…
Clinical Chemistry and …, 2025
degruyterbrill.com
Measuring free drug concentrations in plasma (or serum) involves separating unbound fractions using methods such as equilibrium dialysis (ED), ultrafiltration (UF), ultracentrifugation, or gel filtration, followed by analysis through measurement procedures like LC-MS/MS, immunoassay, or spectrophotometry. While ED is considered the reference method, UF is becoming increasingly popular in clinical laboratories due to its efficiency, speed, and ability to process multiple samples quickly. Various commercial UF devices are …
