Real-world epidemiological outcomes of biologic therapy for chronic rhinosinusitis with nasal polyps: a big data analysis
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E Zloczower, GG Nyquist, A Bebin, Y Lahav…
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pubmed.ncbi.nlm.nih.gov
Background Biologic therapy has emerged as a key treatment for chronic rhinosinusitis with nasal polyps (CRSwNP), particularly in refractory cases, but its effect on healthcare utilization is not well established. Methodology We conducted a retrospective big-data analysis using the Clalit Health Services database, identifying all CRSwNP patients treated with dupilumab or mepolizumab following endoscopic sinus surgery (ESS) between 2010-2024. We assessed antibiotic and systemic steroid use, visits to clinics, emergency rooms …
