Oral delivery of biologically active parathyroid hormone
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DOI:
文献链接: https://pubmed.ncbi.nlm.nih.gov/11496956/
其他信息:
A Leone-Bay, M Sato, D Paton, AH Hunt…
Pharmaceutical …, 2001
Springer
Abstract Purpose. Parathyroid hormone (PTH), the only drug known to stimulate bone formation, is a peptide therapeutic indicated in the treatment of osteoporosis. Unfortunately, PTH is only effective when dosed by injection because it has no oral bioavailability. Herein we report the oral absorption of PTH in rats and monkeys facilitated by the novel delivery agent, N-[8-(2-hydroxy-4-methoxy) bensoyl] amino caprylic acid (4-MOAC). Methods. 4-MOAC was selected from a group of 100 delivery agents based on in vitro chromotography …
