Effects of 3-hydroxydecanoic acid on skin cells: anti-inflammatory, anti-allergic and anti-pruritic activities
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Z Xue, C Shen, Q Meng
Natural Product Research, 2025
Taylor & Francis
Hydroxydecanoic acid (3-HDA) as one hydroxylated fatty acid in royal jelly has limited research on the potential application. This paper investigated the anti-inflammatory properties of 3-HDA on RAW264. 7 murine macrophages, RBL-2H3 rat mast cells and HaCaT human keratinocytes. 3-HDA inhibited lipopolysaccharide (LPS)-induced morphological differentiation of RAW264. 7 cells and reduced subsequent expressions on reactive oxygen species (ROS), TNF-α, cyclooxygenase-2 (COX-2) and prostaglandin E2 …
