TL1A Inhibitors in IBD‐Mechanistic Rationale and Clinical Evidence
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MK Goyal, H Srivastava, T Sehgal…
Alimentary …, 2026
Wiley Online Library
Background Tumour necrosis factor‐like ligand 1A (TL1A) and its receptor DR3 form a pivotal signalling dyad linking immune activation, epithelial barrier dysfunction and fibrogenesis in inflammatory bowel diseases.(IBD). Aims This narrative review summarizes the molecular biology of the TL1A–DR3 axis, its roles in intestinal inflammation, fibrosis, and extraintestinal manifestations, and the emerging therapeutic landscape of TL1A inhibition in IBD. Methods Narrative synthesis of preclinical, translational, and clinical literature on …
