期刊论文Intestine Specific Ablation of Acyl-CoA Synthetase 5 (ACSL5) Increases Satiety and Protects Against Diet Induced Obesity复制

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JD Griffin
2018
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The intestine is recognized as an absorptive organ, facilitating the internalization of nutrients from the diet for use by the body. In addition to this canonical role a growing body of research has established the intestine as an active regulator of energy homeostasis. Through multiple signaling mechanisms the intestine is capable of modifying whole body energy balance in response to dietary components such as fatty acids (FA). Altering normal intestinal FA absorption dysregulates these signaling networks and has the potential to …