Casein kinase 1α essentially regulates thrombopoiesis by driving megakaryocyte maturation and cytoskeleton organization
1. 当前求助状态已完结, 请及时下载应助文件
2. 系统将在 2026-01-27 15:26:01 删除文件
注: 所有应助的资源仅供学习交流使用, 不得违反相关法律法规
DOI:
文献链接:
其他信息:
F Kollotzek, K Mott, M Fischer, B Findik, V Göb…
Blood, 2025
ashpublications.org
Throughout thrombopoiesis megakaryocytes (MKs) form proplatelets within the bone marrow (BM) and release platelets into BM sinusoids. Casein kinase 1α (CK1α) is a major player and thus, an important therapeutic target in several hematological malignancies. This study aimed to define the role of CK1α for the essential steps of thrombopoiesis and to dissect potential mechanisms of thrombocytopenia. MK-specific CK1α-deficiency resulted in a macrothrombocytopenia. Ck1α Pf4Δ/Pf4Δ mice displayed a substantial BM hyperplasia …
