Carbomer inhibits tryptic proteolysis of luteinizing hormone-releasing hormone and N-α-benzoyl-l-arginine ethyl ester by binding the enzyme
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GF Walker, R Ledger, IG Tucker
Pharmaceutical research, 1999
Springer
Purpose. To determine the mechanism by which Carbomer inhibits the enzymatic activity of trypsin in hydrolysis of N-α-benzoyl-L-arginine ethyl ester (BAEE) and luteinizing hormone-releasing hormone (LHRH). Methods. Inhibition of enzymatic activity was studied by measuring the formation of metabolites from LHRH and BAEE. Binding of trypsin and substrates to 0.35%(w/v) Carbomer at pH 7.0 was studied by centrifugal filtration. Gel filtration and reverse phase HPLC was used to determine the stability of trypsin. Results …
