OP0102 Efficacy and Safety of Xeligekimab in Radiographic Axial Spondyloarthritis: Results from a Phase 3 Trial
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S Zhang, D Xu, X Wang, S Liu, F Yuan, W Gou…
Annals of the Rheumatic …, 2025
Elsevier
Background: Radiographic axial spondyloarthritis (r-axSpA), also known as ankylosing spondylitis (AS), is a chronic inflammatory autoimmune disease. Interleukin-17A (IL-17A), a cytokine, plays a key role in the pathogenesis of AS. Xeligekimab (GR1501), a fully human monoclonal antibody that selectively neutralizes IL-17A, has demonstrated potential efficacy in treating r-axSpA. This study represents the first phase 3 clinical trial evaluating Xeligekimab as a treatment for r-axSpA. Objectives: This phase 3 study aimed to determine …
