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Molecules in pathogenesis: angiotensin converting enzyme 2 (ACE2)病理机制中的分子:血管紧张素转化酶 2(ACE2)复制

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O Wiese, AE Zemlin, TS Pillay
Journal of Clinical Pathology, 2021
jcp.bmj.com
The renin–angiotensin system is mainly associated with the regulation of blood pressure, but recently many other functions of this system have been described. ACE2, an 805-amino acid monocarboxypeptidase type I transmembrane glycoprotein, was discovered in 2000 and has sequence similarity to two other proteins, namely ACE and collectrin. The ACE2 gene is located on Xp22 and is highly polymorphic. ACE2 is expressed in numerous tissues especially the lung alveolar epithelial cells, heart, kidney and gastrointestinal tract. Animal …

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2026-01-12 14:31:32 [发起求助]